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Ph.D Research, Biomedical Engineering
Duke University; Durham, NC

Dissertation work:
  • Improved techniques to include real-world population variability in computational biology models, allowing more realistic, clinically-relevant interpretation of model results. Applied to computational models of heart rhythm.
  • Uncertainty quantification and sensitivity analysis techniques:
  • Statistical methods:
    • Bayesian inference
    • non-parametric methods including kernel density estimation
    • hypothesis testing
    • ANOVA and ANCOVA
    • multiple regression
    • nonlinear regression
    • and more!
  • Developed novel visualizations of uncertainty/variability in model results.
Other work:
  • Model development of ion channel mutation effects on heart rhythm (Hodgkin-Huxley style model of ionic current, incorporated into existing models of cardiac action potential); estimated model parameters from experimental data.
  • Also worked with cellular automaton model of cardiac conduction and Markov chain models of ion channels.
  • Performed in vitro imaging of cardiac action potentials (APs).
  • Developed graphical data analysis tool in MATLAB for signal processing and analysis of experimental AP data; improved usability and flexibility over previously used LabView tool.

Junior Editor (Independent Contractor)
American Journal Experts; Durham, NC
2011; 2014

  • Copyedited confidential, unpublished bioengineering manuscripts from international authors with limited English proficiency for submission to American and British journals. Performance consistently rated 4.25 or better on a 5-point scale.
  • Consistently met 24- and 72-hour deadlines for multiple weekly assignments. Worked remotely with managing editors and translators across the U.S. using only electronic communication.

Programmer and Data Analyst
Mediwave Star Technology; Greensboro, NC

  • With no previous FORTRAN knowledge, given approximately 1500 lines of existing FORTRAN code for ECG analysis software. Within 4 weeks, was extending code to implement and test new signal processing and data analysis algorithms with new assignments from Chief Science Officer weekly.
  • Accelerated algorithm prototyping at least 50% within 4 weeks after migrating to Python (no previous Python knowledge), working by e-mail and phone with New Mexico team member.
  • Wrote successful SBIR grant application with Chief Science Officer and local and remote team members.
  • Trained two new hires in FORTRAN and Python data analysis.


  • Ph.D (Biomedical Engineering), Duke University, September 2014
  • M.S. (Biomedical Engineering), Duke University, May 2010
  • B.S. (Physics), University of North Carolina at Greensboro, May 2004

Software and Programming Skills

Programming, Scripting, and Markup Languages

  • Python
  • C++
  • C
  • FORTRAN (F77 and F90)
  • awk
  • bash/csh shell scripting
  • TeX/LaTeX

Mathematics, Statistics, and Scientific Software

  • R
  • Mathematica
  • LabView
  • Numbers (Apple Productivity Apps)
  • Excel (Microsoft Office)

Visualization, Design, and Presentation Software

  • Adobe Illustrator
  • Adobe Photoshop
  • Pages (Apple Productivity Apps)
  • Keynote (Apple Productivity Apps)
  • Word (Microsoft Office)
  • PowerPoint (Microsoft Office)

Publications and Papers

  • Caroline L. Ring, Wanda Krassowska Neu, and Omar M. Knio. “Uncertainty in the Bifurcation Diagram of Cardiac Action Potential Duration.” In Dynamics Days US 2014: Book of Abstracts, page 139, 2014.
  • Caroline L. Ring, David Schaeffer, and Wanda Krassowska Neu. “Effect of strength-interval relationship on cardiac rhythm dynamics in a one-dimensional mapping model.” In Dynamics Days 2011: Abstracts, pages 32-33, 2011.
  • Caroline L. Ring, Salim F. Idriss, and Wanda Krassowska Neu. “Variability of action potential duration in pharmacologically induced long QT syndrome type 1.” In Conference proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Conference, vol. 2009, pp. 4520-4522, 2009. doi:10.1109/IEMBS.2009.5334105